Animal Infectious Diseases

Monkeypox virus (MPXV) A35 protein: The A35R protein expressed by monkeypox A35R gene is homologous to A33R in vaccinia virus. Studies have shown that A33R in vaccinia virus plays a crucial role in the spread of virus particles between cells and is an important target for vaccine development. Studies have shown that A35R is a potential target for serological detection of monkeypox virus. Monkeypox virus (MPXV) A29 protein: There are few studies on the structure and function of monkeypox virus A29 protein, but it is homologous to A27 protein in vaccinia virus (VACV). Literature reports that the A29 protein of monkeypox virus is a target of a specific monoclonal antibody against monkeypox virus. The envelope protein A27 of vaccinia virus has multiple functions. It can bind to cell surface heparan sulfate, provide an anchor for VACV A26 protein to package into mature virus particles, and is critical for the release of mature virus particles (MV) from infected cells. The crystal structure of A27 protein has been resolved, providing a scientific basis for the development of antiviral drugs in the Orthopoxvirus genus. Monkeypox virus (MPXV) H3L protein: The H3L protein expressed by monkeypox H3L gene is homologous to H3L in vaccinia virus. Studies have shown that H3L binds to host cell surface heparan sulfate and plays an important role in the process of virus particle invasion into host cells. H3L is an important target for vaccine development and also a target for the production of protective neutralizing antibodies. Monkeypox virus (MPXV) I1L protein: The I1L protein expressed by monkeypox I1L gene is homologous to I1L in vaccinia virus. It is one of the late-expressed proteins of monkeypox virus and is a DNA-binding protein that binds to the hairpin structure of viral telomere sequences. Monkeypox virus (MPXV) L1R protein: The L1R protein expressed by monkeypox L1R gene is homologous to J1R in vaccinia virus. Studies have shown that J1R in vaccinia virus is a membrane protein required for viral growth and plaque formation. J1R interacts with A45R protein and plays an important role in the formation of immature virus particles.

Vaccinia virus is a member of the Poxvirus genus and is closely related to variola virus and cowpox virus in serology and immunology. It is used as an antigen for smallpox prophylactic vaccines. The A27 protein of vaccinia virus (VACV-A27) has 95% homology with the A29 protein of monkeypox virus and is also a viral envelope protein that mediates the recognition of the virus by host cells. It can be used as a material for detection and cross-interference analysis.

Cowpox virus is a virus that can cause mild cowpox lesions in cows. Cowpox virus is similar to monkeypox virus and both belong to the genus Orthopoxvirus. The cowpox virus 162 protein (CPXV-162) and the monkeypox virus A29 protein are highly homologous, with a homology of 95%. They are both envelope proteins of the virus that mediate the recognition of the host cell by the virus and can be used as materials for detection and cross-interference analysis.