Cytokine

Interleukin-8 is an early inflammatory cytokine produced by many cells with chemotactic effect, an important regulator of neutrophil activation and migration, and an important medium for entering injured tissues. It is a cytokine that plays an important role in the pathological process of injury. Many studies have proved that high levels of IL-8 can be detected in serum and local areas of patients with infection, trauma, hypoxia, ischemia and autoimmune diseases, and the increase of IL-8 is related to the progression and outcome of the disease.

Interleukin-10, known as cytokine synthesis Inhibitor (CSIF), is a pleiotropic cytokine that can play an immunosuppressive or immunostimulating role in a variety of cell types. It is a 35-40kd acidic protein composed of two homologous subunits and is an inhibitory lymphofactor mainly secreted by Th 2 cells. IL-10 has a strong anti-inflammatory effect, which can inhibit the synthesis and activity of some factors such as IL-2, IL-1-β, IFN-γ, TNF-α and so on. At the same time, it has a positive regulatory effect against inflammatory substances such as IL-1Ra. Therefore, it is generally believed that IL-10 may be an effective anti-inflammatory substance in many pathological conditions, and it is worth studying in the treatment prospect of chronic inflammatory diseases. IL-10 also inhibits T cell subsets of cytokines, so IL-10 is expected to extend the survival time of allografts and treat autoimmune diseases mediated by various T cells, such as type I diabetes and multiple sclerosis.

Il-1β is one of the molecular forms of IL-1 and contains 153 amino acids. 1, local effects Local low concentration of IL-1 mainly plays an immunomodulatory role. ① Synergistic with antigen, CD4+T cells can be activated, IL-2R expression;②Promoting the growth and differentiation of B cells,which can increase the number of hemolytic plaque (PFC) of spleen cells by 100 times, indicating that IL-1 also promotes the formation of antibodies; ③ Promote the antigen-presenting ability of APC such as mononuclear macrophages;④Synergism with IL-2 or interferon can enhance the activity of NK cells; ⑤ Attract neutrophils, causing the release of inflammatory mediators; ⑥ stimulate a variety of different interstitial cells to release proteinolytic enzymes and produce some effects. ⑦IL-1 also has certain effects on chondrocytes, fibroblasts and bone metabolism. 2. Systemic effects Animal experiments have shown that large amounts of IL-1 secretion or injection can cause systemic reactions through the blood circulation.

CFL1 is a ubiquitous protein that regulates cell cycle and cell functions such as proliferation, apoptosis and excitotoxic neurodegeneration. Increased CFL1 expression is associated with the progression of certain tumor types and metastases. CFL1 is a possible molecular marker to evaluate the incidence and progression of prostate cancer, and it may be one of the effective targets for molecular therapy of prostate cancer in the future.